Faculty Profile
Babu Tekwani (Faculty Member is Retired, or has otherwise left the University)
Professor of Pharmacology
Phone Number: (662)915-7882
Email: btekwani@olemiss.edu
http://pharmacy.olemiss.edu/php/sopquery3.php?id=71
Key Words: Drug Discovery, Drug Action, Pharmacology, Biochemistry, Molecular Biology, Pharmacokinetics, Malaria, Tropical Diseases, Global Health, Neuroscience, Neurodegenerative Diseases, Neurological Disorders, Natural Products
Research Description: Biochemistry, Molecular Biology, Pharmacology, Genomics of Eukaryotic Pathogens; New Drug Discovery Research. Comparative functional & structural genomics of common target pathways/enzymes of eukaryotic pathogens (Plasmodium falciparum; Leishmania donovani and Trypanosoma brucei). In vitro screening (molecular target-based and cell based assays); Development of assays and High Throughput Screening; Molecular cloning, overexpression, functional characterization and validation of potential target enzymes; Molecular basis of pathogenesis of the disease caused by eukaryotic pathogens; In vitro drug metabolism and drug-drug interactions; Laboratory animal models of the disease (malaria & leishmaniasis) and in vivo screening; New insights into to mechanism of drug induced hemolytic toxicity; In vitro assays for prediction of hemolytic toxicity potential of drugs. Natural Products drug leads neurological disorders and neurodegenerative diseases Epigenetic mechanism of neuronal cells' differentiation; In vitro screening of natural products for effects on neuritic outgrowth.
Honors Theses:
Higginbotham, Robert Tyrone (2018) Evaluation of New Antimalarial Drug Combinations (full text)
Available Research Projects:
Discovery new drugs for treatment of Malaria and tropical parasitic diseases
Project Description: Genomics of Eukaryotic Pathogens; New Drug Discovery Research. Comparative functional & structural genomics of common target pathways/enzymes of eukaryotic pathogens (Plasmodium falciparum; Leishmania donovani and Trypanosoma brucei). In vitro screening (molecular target-based and cell based assays); Development of assays and High Throughput Screening; Molecular cloning, overexpression, functional characterization and validation of potential target enzymes; Molecular basis of pathogenesis of the disease caused by eukaryotic pathogens; In vitro drug metabolism and drug-drug interactions; Laboratory animal models of the disease (malaria & leishmaniasis) and in vivo screening; New insights into to mechanism of drug induced hemolytic toxicity; In vitro assays for prediction of hemolytic toxicity potential of drugs.
Desired Student Qualifications: Biology, Chemistry & Biochemistry; Pharmacy; Pre-pharmacy
Project Timeline:
Duties of Student Researcher: Study mechanism of action of new drug leads, In vitro screening assays.
Last Updated on 2015-09-29 16:14:01
Natural Products drug leads neurological disorders and neurodegenerative diseases
Project Description: Natural Products drug leads neurological disorders and neurodegenerative diseases Epigenetic mechanism of neuronal cells' differentiation; In vitro screening of natural products for effects on neuritic outgrowth
Desired Student Qualifications: Biology, Chemistry & Biochemistry; Pharmacy; Pre-pharmacy
Project Timeline:
Duties of Student Researcher: In vitro screening of natural products for effects on neuritic outgrowth
Last Updated on 2015-09-29 16:15:35