Dale Nagle
Professor of BioMolecular Sciences
Phone Number: (662)915-7143
Email: dnagle@olemiss.edu
http://pharmacy.olemiss.edu/biomolecularsciences/team/dr-dale-g-nagle

Key Words: discovery of new drugs, biomedical potential of natural products, tumor differentiation and cell death,

Research Description: Dr. Nagle's research focuses on the discovery of new drugs. His program combines natural products chemistry with cutting edge molecular mechanism-targeted bioassay techniques. Dr. Nagle explores the biomedical potential of natural products as new sources of drug leads for the treatment of cancer. He and Dr. Yu-Dong Zhou (Department of Chemistry and Biochemistry) have developed new molecular-based bioassays to investigate natural products for their potential to supplement existing chemotherapeutic agents by acting as promoters of tumor differentiation and cell death. Dr. Nagle's research examines new methods to rapidly detect the presence of potentially useful anticancer agents that target specific biochemical mechanisms involved in the development and spread of tumors. Dramatic progress during the past two decades has led to the identification of many genes involved in tumorigenesis and cancer progression, the molecular mechanisms underlying how these genes function, as well as the biochemical/physiological conditions required for tumor growth and metastatic spread. These have revolutionized antitumor drug discovery from traditional cytotoxic methods to more mechanism-based molecular-targeted approaches. Specifically, our research is now aimed at the discovery of new non-cytotoxic molecular-targeted antitumor agents.

Honors Theses:

McNeely, Meghan Houston (2018) Cardiolipin Profiling in Metastatic Breast Cancer Cells (full text)

Noblin, Ashley E. (2016) Exploration of Compound Viability as an Organ-Selective Anti-Metastatic Therapeutic Treatment for Triple Negative Breast Cancer. (full text)