David Colby
Associate Professor of Medicinal Chemistry
Phone Number: (662)915-1766
Email: dacolby@olemiss.edu
https://colbylab.com

Key Words: Medicinal chemistry, organic chemistry, drug design, natural products

Research Description: In our laboratory, we seek to use compounds isolated from nature, or natural products, for drug discovery and the development of dietary supplements. We blend the science of medicinal chemistry and synthetic organic chemistry through the use of natural products chemistry, natural product synthesis, and the design of structural analogues for structure-activity investigations. Our group develops therapeutics for diseases that have no or few existing treatment options, including neurodegenerative disorders, drug addiction, and cancer. We are also developing novel synthetic methods to modify complex organic molecules and to install fluorine.

Honors Theses:

Kreusel, Katherine Elizabeth (2022) Synthesis of Fluorinated Ketones for Biological Evaluation at the GABA-B Receptor (full text)

Griffin, Madeline (2020) Synthesis of Aromatic Fluorinated Ketones for Evaluation at the GABA Receptor (full text)

Baldwin, Cassidy S. (2018) Technique for the Synthesis of Difluorinated Organic Molecules Using Magnesium Bases (full text)

Maier, Mallory (2017) Synthesis of Difluoromethyl and Monofluoromethyl Ketones for Biological Evaluation at the GABA-b Receptor. (full text)