John Rimoldi
Professor of Medicinal Chemistry
Phone Number: (662)915-5119
Email: jrimoldi@olemiss.edu
http://www.pharmacy.olemiss.edu/medicinal_chemistry/rimoldi.html

Key Words: Bioactive Amines, In-Vitro Drug Metabolism, Small-Molecule Enzyme Probes, Bioorganic Chemistry, Environmental Toxicology, Structure-Activity Relationships, Parallel Synthesis, Synthetic Methodology, Solid-Phase Reagent Development, Naturally Occurring Neu

Research Description: Our research efforts involve the design, syntheses, and biological evaluation of both synthetically derived and natural product-based compounds for treatment of a variety of diseases. We use synthetic organic chemistry, molecular modeling, and parallel-combinatorial techniques as tools to investigate biological processes implicated in various diseases.

Honors Theses:

Hammond, Rachel Irene (2022) Synthetic Investigations in Chemical Probe Development Part 1: Design and Synthesis of Novel Triton X-405 Adenosine Conjugates; Part 2: Synthesis of 2,8-Dihydroxychrysene (full text)

Bettiga, Eli (2021) Synthesis of Novel Long Chain Unsaturated Fatty Acid Analogs of Capsaicin (full text)

Patrick, Ann K. (2020) Approaches Towards the Synthesis of Ketamine Metabolites (full text)

Edwards, Isaiah (2020) Synthesis of Pharmaceutical and Personal Care Products and Pesticide Metabolites of Environmental Concern (full text)

Street, Margaret Ann (2019) Modification of HIV-1 Protease Inhibitor Pharmacophore to Assess Anti-Malarial Properties (full text)

Fairley, Savannah (2018) Synthesis of (2R,6R)-Hydroxy-norketamine for Evaluation of Antidepressant Effects (full text)

Thrash, Mary Paige (2018) Design and Synthesis of Novel Cannabinoid Receptor Modulators (full text)

Cole, Mariah Leigh (2017) Synthesis and Biological Evaluation of Cannabinoid Receptor Ligands. (full text)

Gust, William (2017) The Pharmacodynamic Functions of Low-Dose Rapamycin as a Model for Universal Influenza Protection. (full text)

Wood, Alexandra M (2014) Synthesis of a New Scytovirin Protein Derivative, Sd1-Sd2-Sd2, to Decrease Hiv-1 Binding Affinity. (full text)

Kishk, Omayma Ahmed (2010) "Mimics of Adhesive Biomaterials: Synthesis of Peptoid Oligomer Incorporating Dihydroxyphenyl Side Chains"

Peel, Robert Kelly (2010) "Reaction of the Plant Neurotoxin Repin with Various Amines"