Faculty Profile
Joshua Sharp
Assistant Professor of Pharmacology
Phone Number:
Email: jsharp@olemiss.edu
http://pharmacy.olemiss.edu/biomolecularsciences/team/dr-joshua-sharp/
Key Words: Protein Structures, Carbohydrate Structures, Mass Spectrometry
Research Description: Dr. Sharp’s group is active in the development and application of new mass spectrometry-based technologies for studying the structure-function relationships of proteins and carbohydrates of biomedical interest. Current applications focus on the study of interactions between neutralizing antibodies and the glycoprotein coat of HIV; characterization of chemokines and the structural factors mediating their oligomerization and function; and the identification of glycosaminoglycan structures with potential biomedical applications for a wide variety of fields including anti-microbial agents, anti-cancer therapies, and anti-inflammatory therapies.
Honors Theses:
Morrow, Elaine (2022) Fast Photochemical Oxidation and Footprinting of Proteins Via Trifluoromethyl Radical Chemistry (full text)
Roush, Addison (2020) Intrinsic Buffer Hydroxyl Radical Dosimetry for Hydroxyl Radical Protein Footprinting (full text)
Available Research Projects:
Protein-Protein Interactions by Mass Spectrometry
Project Description: Protein structure lies at the heart of protein function. However, many proteins are prohibitively difficult to study using traditional structural techniques. We are developing new technologies for measuring changes in protein topography, and using these technologies to characterize protein-protein and protein-ligand interaction interfaces. We are also characterizing changes in protein dynamics and conformation that occur upon binding.
Desired Student Qualifications: Successful completion of introductory courses in chemistry required. Successful completion of organic chemistry and instrumental analysis preferred. Background in biology or biochemistry preferred. Basic laboratory skills preferred. Minimum of ten hours per week required.
Project Timeline: Ongoing
Duties of Student Researcher: Assist in development and application of hydroxyl radical protein footprinting technologies. Assist in the operation and maintenance of high resolution liquid chromatography-mass spectrometry system. Assist in the development of new projects. Perform lab duties as required.
Last Updated on 2016-08-30 20:52:22