Sudeshna Roy
Assistant Professor Of Medicinal Chemistry And Pharmacognosy of BioMolecular Sciences
Phone Number: (662)915-2980
Email: roy@olemiss.edu
https://pharmacy.olemiss.edu/biomolecularsciences/team/dr-sudeshna-roy/

Key Words: chemistry, medicinal chemistry, organic chemistry, synthetic methods, drug discovery

Research Description: The Roy laboratory is focused on developing new technologies at the interface of chemistry and biology. To this end we explore and develop new methods to synthesize small molecules and apply them in various drug discovery programs against drug-resistant infectious diseases and new cancer targets.

Drug-resistant infections present a global health risk that need urgent scientific interventions. In the United States alone, two million people become infected with antibiotic-resistant bacteria leading to 23,000 deaths each year. Unfortunately, our arsenal of new drugs is insufficient to combat the multi-drug resistant and extreme-drug resistant bacteria, commonly known as “superbugs”. To this end, the Roy laboratory is working on developing new antibiotics or chemotherapeutic agents to combat this growing challenge of antibacterial resistance.

We are also interested in developing technologies around fluorine-containing compounds. Fluorinated molecules confer unique pharmacokinetic properties and binding interactions and contain 100% abundant ¹⁹F natural isotope. We are creating new technologies to synthesize fluorinated compounds that could be used in various drug discovery platforms.

Honors Theses:

Saucier, Matthew (2020) Synthesis of Fluorinated Pyrazoles via Intra- and Intermolecular Cyclization Reactions (full text)

Stewart, Micah (2020) Silver-Catalyzed Synthesis of Disubstituted Fluorinated Isoxazoles (full text)

McCluggage, Peggy (2020) Design and Synthesis of Novel Analogs as Potential Antitubercular Agents (full text)

Available Research Projects: