Faculty Profile
Ziaeddin Shariat-Madar
Associate Professor of Pharmacology
Phone Number: (662)915-5150
Email: madar@olemiss.edu
http://pharmacy.olemiss.edu/php/sopquery3.php?id=232
Key Words: Drug discovery, plasma kallikrein kinin system, inflammation, diabetes, and senescence
Research Description: Dr. Shariat-Madar is a biomedical scientist whose research has focused on the physiological role of plasma kallikrein kinin system (KKS), including application to human health and disease.
Honors Theses:
Sneed, Logan (2021) HIV Tat Protein Activates Plasma Kallikrein-Kinin System in HIV-1 Tat Transgenic Mice (full text)
Crosswhite, Betsy (2018) Inhibition of Blood Coagulation Factor XII: Evaluation of Flavonoids as a Drug Candidate (full text)
Bensel, Alexandra C. (2016) Identification of Inhibitors of FXII. (full text)
Boullard, Nicholas (2014) Cardiovascular Protective Agents and their Biochemical Role in Endothelial Cell Senescence. (full text)
Isani, Mubina Aziz (2008) "The Expression and Characterization of Full-Length PRCP in Chinese Hamster Ovary Cells" (full text)
Ngo, My-Linh Dinh (2008) "Lipopolysaccharide Pretreatment of Endothelial Cells Modifies Prolylcarboxypeptidase Expression and Function In Vitro"
Perkins, Ryan Cory (2008) "Characterization of the Lipopolysaccharide Binding Site on the Plasma Protein High Molecular Weight Kininogen" (full text)
Available Research Projects:
Drug discovery
Project Description: The student will identify the role of food-based bioactive compounds in reducing the activity of prolylcarboxypeptidase, kallikrein, or activated factor XII.
Desired Student Qualifications: Prerequisites:The student must be highly motivated and responsible. No prior knowledge of the topic is required
Project Timeline: 6 to 12 months
Duties of Student Researcher:
Last Updated on 2014-09-05 09:50:05
Inflammation
Project Description: The student will work on core features of prolylcarboxypeptidase (protease)-induced inflammation.
Desired Student Qualifications: Prerequisites:The student must be highly motivated and responsible. No prior knowledge of the topic is required
Project Timeline: 6 to 12 months
Duties of Student Researcher:
Last Updated on 2014-09-05 09:38:08
Prolylcarboxypeptidase
Project Description: Prolylcarboxypeptidase (PRCP) has the potential to be a therapeutic target for inflammatory diseases. We would like to explore whether PRCP can serve as a prognostic marker
Desired Student Qualifications: Prerequisites: No prior knowledge of the topic is required. I need a student to start working on the project in Fall 2017 or Spring 2018.
Project Timeline: 6 to 12 months
Duties of Student Researcher:
Last Updated on 2017-09-26 10:13:20